Roberta Noberini

Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

TCA cycle rewiring underpins implantation and histone acetylation programming

This study reveals that TCA cycle rewiring at implantation supports histone acetylation programming and pluripotency transitions in mouse embryos.

Palmitate-induced mitochondrial damage restricts histone acetylation in CD8+ T cells to impair anti-tumor immunity.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

Metabolic and age-associated epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes

This study identifies metabolic and age-related epigenetic barriers in converting mouse fibroblasts to induced cardiomyocytes, showing that metabolic modulation enhances reprogramming efficiency.

Detection and quantification of the histone code in the fungal genus Aspergillus

The paper detects and quantifies histone post-translational modifications (PTMs) in three Aspergillus species, revealing strain-specific variations in PTM abundance and novel PTMs.

7q11.23 CNV alters protein synthesis and REST-mediated neuronal intrinsic excitability

This study investigates how 7q11.23 CNVs affect protein synthesis and neuronal excitability in neurodevelopmental disorders using patient-derived neurons and multi-omics approaches.