Author

S. A. Best

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

J. R. Whittle· 2 shared L. Freytag· 2 shared S. Freytag· 2 shared A. P. Morokoff· 1 shared A. Pavenko· 1 shared B. L. Patenall· 1 shared C. D. Schmults· 1 shared C. G. Lian· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

J. R. Whittle

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3 papers

Recent·Most cited

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

K. Kay, J. Lee, E. S. Hong, J. Beilis, S. Dayal, E. R. Wesley, S. Mitchell, S. Z. Wang, D. J. Silver, J. Volovetz, S. Johnson, M. McGraw, M. M. Grabowski, T. Lu, L. Freytag, , J. Lathia

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

bioRxiv · Nov 14, 2023Cancer Biology

PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

R. Boudra, B. L. Patenall, S. King, D. Wang, S. A. Best, J. Y. Ko, S. Xu, M. G. Padilla, C. D. Schmults, S. R. Barthel, C. G. Lian, M. R. Ramsey

This study identifies BNC1-PRMT1 as a transcriptional axis promoting SCC growth, showing PRMT1 inhibition reduces tumor size without affecting migration.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Spatial architecture of high-grade glioma reveals tumor heterogeneity within distinct domains

J. J. D. Moffet, O. E. Fatunla, L. Freytag, J. J. Jones, S. J. Roberts-Thomson, A. Pavenko, D. K. Scoville, L. Zhang, Y. Liang, A. P. Morokoff, J. R. Whittle, S. Freytag, S. A. Best

This study uses spatial technologies to analyze high-grade gliomas, revealing distinct tumor niches and immune interactions linked to intra-tumoral heterogeneity.

bioRxiv · Mar 13, 2023Cancer Biology