Author

S. A. Handley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1 Organism:virus· 1

Frequent Co-Authors

A. Jung· 2 shared L. Droit· 2 shared A. B. Janowski· 1 shared A. C. Boon· 1 shared B. A. Parikh· 1 shared B. Febles· 1 shared B. Guarino· 1 shared C. Fujii· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

A. Jung

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

A. B. Janowski, H. Jiang, C. Fujii, M. C. Owen, T. L. Bricker, T. L. Darling, H. H. Harastani, K. Seehra, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. A. Handley, B. A. Parikh, V. Lulla, , D. Wang

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

bioRxiv · Apr 30, 2022 · PreprintMicrobiology

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

J. B. Case, S. Mackin, J. Errico, Z. Chong, E. A. Madden, B. Guarino, M. A. Schmid, K. Rosenthal, K. Ren, A. Jung, L. Droit, S. A. Handley, P. J. Halfmann, Y. Kawaoka, J. E. Crowe, , M. S. Diamond

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

bioRxiv · Mar 17, 2022Microbiology

Human enteric viruses shape disease phenotype through divergent innate immunomodulation

F. Adiliaghdam, H. Amatullah, S. Digumarthi, T. L. Saunders, R.-U. Rahman, L. P. Wong, R. Sadreyev, L. Droit, J. Paquette, P. Goyette, J. Rioux, R. Hodin, K. Mihindukulasuriya, S. A. Handley, K. L. Jeffrey

The paper shows that human viromes from healthy and IBD patients differentially modulate innate immunity, influencing disease phenotypes through nucleic acid sensing.

bioRxiv · Oct 14, 2021 · PreprintImmunology