Author

L. Droit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. B. Case· 3 shared D. Corti· 2 shared D. H. Fremont· 2 shared D. Wang· 2 shared H. W. Virgin· 2 shared H. Zhao· 2 shared J. E. Crowe· 2 shared M. S. Diamond· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersMicrobiology

J. B. Case

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

J. B. Case, S. Mackin, J. Errico, Z. Chong, E. A. Madden, B. Guarino, M. A. Schmid, K. Rosenthal, K. Ren, A. Jung, L. Droit, S. A. Handley, P. J. Halfmann, Y. Kawaoka, J. E. Crowe, , M. S. Diamond

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

bioRxiv · Mar 17, 2022Microbiology

Human enteric viruses shape disease phenotype through divergent innate immunomodulation

F. Adiliaghdam, H. Amatullah, S. Digumarthi, T. L. Saunders, R.-U. Rahman, L. P. Wong, R. Sadreyev, L. Droit, J. Paquette, P. Goyette, J. Rioux, R. Hodin, K. Mihindukulasuriya, S. A. Handley, K. L. Jeffrey

The paper shows that human viromes from healthy and IBD patients differentially modulate innate immunity, influencing disease phenotypes through nucleic acid sensing.

bioRxiv · Oct 14, 2021 · PreprintImmunology

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

L. VanBlargan, L. Adams, Z. Liu, R. E. Chen, P. Gilchuk, S. Raju, B. Smith, H. Zhao, J. B. Case, E. S. Winkler, B. Whitener, L. Droit, I. Aziati, P.-Y. Shi, A. Creanga, , M. Diamond

The paper identifies an antibody that neutralizes all SARS-CoV-2 variants by targeting a conserved epitope on the spike protein.

bioRxiv · Apr 26, 2021Microbiology

Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.

J. B. Case, P. W. Rothlauf, R. E. Chen, Z. Liu, H. Zhao, A. S. Kim, L.-M. Bloyet, Q. Zeng, S. Tahan, L. Droit, M. X. G. Ilagan, M. A. Tartell, G. K. Amarasinghe, J. P. Henderson, S. Miersch, , S. P. J. Whelan

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

bioRxiv · May 18, 2020Microbiology