Author

P. J. Halfmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Y. Kawaoka· 8 shared M. S. Diamond· 3 shared T. Maemura· 3 shared A. K. Haj· 2 shared F. Krammer· 2 shared G. K. Moreno· 2 shared K. M. Braun· 2 shared M. Kuroda· 2 shared

Activity by Year

2020-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

8 shared papersMicrobiology

Y. Kawaoka

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

S. Changrob, P. J. Halfmann, H. Liu, J. L. Torres, J. J. C. McGrath, G. Ozorowski, L. Li, M. Kuroda, T. Maemura, M. Huang, D. G. Wilbanks, N.-Y. Zheng, H. L. Turner, S. A. Erickson, Y. Fu, , P. C. Wilson

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

bioRxiv · Oct 31, 2022Immunology

Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection

A. J. Eisfeld, S. Fan, H. Rao, B. A. Venkatachalam, D. W. Smith, P. J. Halfmann, K. B. Walters, S. Nair, L. B. Thackray, J. F. Kocher, A. C. Sims, H. D. Mitchell, G. Neumann, V. Blank, K. M. Waters, , Y. Kawaoka

The paper identifies novel innate immune regulators affecting influenza virus replication and pathogenesis through experimental validation of network model predictions.

bioRxiv · Aug 29, 2022 · PreprintMicrobiology

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

R. Uraki, S. Iida, P. J. Halfmann, S. Yamayoshi, Y. Hirata, K. Iwatsuki-Horimoto, M. Kiso, M. Ito, Y. Furusawa, H. Ueki, Y. Sakai-Tagawa, M. Kuroda, T. Maemura, T. Kim, S. Mine, , Y. Kawaoka

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

bioRxiv · Aug 26, 2022 · PreprintMicrobiology

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

J. B. Case, S. Mackin, J. Errico, Z. Chong, E. A. Madden, B. Guarino, M. A. Schmid, K. Rosenthal, K. Ren, A. Jung, L. Droit, S. A. Handley, P. J. Halfmann, Y. Kawaoka, J. E. Crowe, , M. S. Diamond

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

bioRxiv · Mar 17, 2022Microbiology

Mapping SARS-CoV-2 antigenic relationships and serological responses

S. H. Wilks, B. Muhlemann, X. Shen, S. Tureli, E. B. LeGresley, A. Netzl, M. A. Caniza, J. N. Chacaltana-Huarcaya, V. M. Corman, X. Daniell, M. B. Datto, F. S. Dawood, T. N. Denny, C. Drosten, R. A. M. Fouchier, , D. J. Smith

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

bioRxiv · Jan 28, 2022Immunology

Nasally-delivered interferon-{lambda} protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron

Z. Chong, C. E. Karl, P. J. Halfmann, Y. Kawaoka, E. S. Winkler, J. Yu, M. S. Diamond

This study shows that nasal delivery of IFN-λ protects mice against SARS-CoV-2 variants including Omicron in both upper and lower respiratory tracts without causing excessive inflammation.

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

K. M. Braun, G. K. Moreno, P. J. Halfmann, E. B. Hodcroft, D. A. Baker, E. C. Boehm, A. M. Weiler, A. K. Haj, M. Hatta, S. Chiba, T. Maemura, Y. Kawaoka, K. Koelle, D. O'Connor, T. Friedrich

This study shows SARS-CoV-2 in cats has limited within-host genetic variation and a narrow transmission bottleneck, with a variant H655Y emerging and spreading across transmission pairs.

bioRxiv · Nov 16, 2020Microbiology

Limited SARS-CoV-2 diversity within hosts and following passage in cell culture

G. K. Moreno, K. M. Braun, P. J. Halfmann, T. M. Prall, K. K. Riemersma, A. K. Haj, J. Lalli, K. R. Florek, T. C. Friedrich, Y. Kawaoka, D. H. O'Connor

This study analyzes SARS-CoV-2 within-host diversity using metagenomic sequencing and finds low genetic variation with limited evidence of positive selection in clinical and cell culture samples.

bioRxiv · Apr 20, 2020 · PreprintMicrobiology