Author

T. L. Darling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Organism:rat· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

T. L. Bricker· 5 shared A. C. M. Boon· 4 shared H. H. Harastani· 3 shared J. B. Case· 3 shared M. S. Diamond· 3 shared A. Joshi· 2 shared B. Ying· 2 shared C.-Y. Liang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersMicrobiology

T. L. Bricker

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters

B. Ying, T. L. Darling, P. Desai, C.-Y. Liang, I. P. Dmitriev, N. Soudani, T. L. Bricker, E. A. Kashentseva, H. H. Harastani, A. G. Schmidt, D. T. Curiel, A. C. M. Boon, M. S. Diamond

This paper shows a bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 in mice and hamsters through mucosal immunity, despite poor serum neutralizing antibody responses.

bioRxiv · May 4, 2023 · PreprintMicrobiology

Characterization of the SARS-CoV-2 BA.5.5 and BQ.1.1 Omicron Variants in Mice and Hamsters

J. B. Case, S. M. Scheaffer, T. L. Darling, T. L. Bricker, L. J. Adams, H. H. Harastani, R. Trende, S. Sanapala, D. H. Fremont, A. C. M. Boon, M. S. Diamond

This paper evaluates the pathogenicity of SARS-CoV-2 BQ.1.1 and BA.5.5 variants in multiple rodent models, finding increased virulence in transgenic mice but not in conventional mice or hamsters.

bioRxiv · Apr 28, 2023 · PreprintMicrobiology

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

A. B. Janowski, H. Jiang, C. Fujii, M. C. Owen, T. L. Bricker, T. L. Darling, H. H. Harastani, K. Seehra, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. A. Handley, B. A. Parikh, V. Lulla, , D. Wang

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

bioRxiv · Apr 30, 2022 · PreprintMicrobiology

mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2

T. L. Darling, B. Ying, B. Whitener, L. VanBlargan, T. L. Bricker, C.-Y. Liang, A. Joshi, G. Bamunuarachchi, K. Seehra, A. Schmitz, P. Halfmann, Y. Kawaoka, S. Elbashir, D. K. Edwards, L. Thackray, , A. Boon

This study evaluates the efficacy of mRNA-1273 and Ad26.COV2.S vaccines against the B.1.621 variant in mice and hamsters, showing protection against infection and pathology.

bioRxiv · Dec 29, 2021Microbiology

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants

A. J. Schmitz, J. S. Turner, Z. Liu, I. D. Aziati, R. E. Chen, A. Joshi, T. L. Bricker, T. L. Darling, D. C. Adelsberg, W. B. Al Soussi, J. B. Case, T. Lei, M. Thapa, F. Amanat, J. A. O'Halloran, , A. H. Ellebedy

A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.

bioRxiv · Mar 24, 2021Immunology

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection

E. S. Winkler, P. Gilchuk, J. Yu, A. L. Bailey, R. E. Chen, S. J. Zost, H. Jang, Y. Huang, J. D. Allen, J. B. Case, R. E. Sutton, R. H. Carnahan, T. L. Darling, A. C. M. Boon, M. Mack, , M. Diamond

This study shows that neutralizing antibodies against SARS-CoV-2 need intact Fc functions and monocytes for optimal therapeutic protection in animal models.

bioRxiv · Dec 28, 2020Immunology