Author

D. Depoil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Siokis· 1 shared E. Abu-Shah· 1 shared E. Mann· 1 shared J. Afrose· 1 shared J. Allard· 1 shared J. Goyette· 1 shared K. Gaus· 1 shared K. Korobchevskaya· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Siokis

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2 papers

Recent·Most cited

Regulated unbinding of ZAP70 at the T cell receptor by kinetic avidity

J. Goyette, D. Depoil, Z. Yang, S. A. Isaacson, J. Allard, P. A. van der Merwe, K. Gaus, M. Dustin, O. Dushek

The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.

bioRxiv · Feb 12, 2020 · PreprintImmunology

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

P. Demetriou, E. Abu-Shah, S. McCuaig, V. Mayya, S. Valvo, K. Korobchevskaya, M. Friedrich, E. Mann, L. Y. Lee, T. Starkey, M. A. Kutuzov, J. Afrose, A. Siokis, Oxford IBD Cohort Investigators, M. Meyer-Hermann, , M. L. Dustin

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.

bioRxiv · Mar 29, 2019 · PreprintImmunology