The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
P. Holfelder, L. Hensen, M. T. Prentzell, P. Razquin Navas, M. Solvay, A. Sadik, D. Sayeeram, U. Rehbein, T. Bausbacher, A.-S. Egger, L. Regin, A. M. Heberle, S. Seifert, A. Leytens, A. Kowar, , S. Harder
This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.
bioRxiv · Jan 16, 2023 · PreprintBiochemistry