S. A. Thannickal

La Crosse virus reassortants highlight genomic determinants of infection and pathogenesis

This study uses genomic reassortment to identify how different segments of La Crosse virus affect infection and pathogenesis in vitro and in vivo.

The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity.

This study investigates how mutations in the CHIKV E1 glycoprotein's fusion loop and hinge affect virus infectivity in different cell types and hosts by altering E1-E2 dynamics.

The La Crosse virus class II fusion glycoprotein ij loop contributes to infectivity and cholesterol-dependent entry.

This study investigates the role of the La Crosse virus (LACV) class II fusion glycoprotein ij loop in infectivity and cholesterol-dependent entry, showing that specific residues are critical for virus function.

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production.

This study identifies structurally conserved domains in flavivirus and alphavirus fusion glycoproteins that contribute to replication and infectious virion production, suggesting potential targets for broad-spectrum antivirals.

Two-dimensional multiplexed assay for rapid and deep SARS-CoV-2 serology profiling and for machine learning prediction of neutralization capacity

This paper introduces a 2D-MBBA assay for SARS-CoV-2 serology profiling and uses machine learning to predict neutralization capacity from antibody profiles.