Author

M. G. Noval

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:mouse· 7 Organism:human· 5 Assay:proteomics· 3 Assay:metagenomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K. A. Stapleford· 9 shared B. A. Rodriguez-Rodriguez· 3 shared M. V. Rangel· 3 shared E. Ghedin· 2 shared K. Cadwell· 2 shared M. Dittmann· 2 shared N. Narula· 2 shared S. A. Thannickal· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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9 shared papersMicrobiology

K. A. Stapleford

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity.

S. A. Thannickal, L. Battini, S. N. Spector, M. G. Noval, D. E. Alvarez, K. A. Stapleford

This study investigates how mutations in the CHIKV E1 glycoprotein's fusion loop and hinge affect virus infectivity in different cell types and hosts by altering E1-E2 dynamics.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

SARS-CoV-2 infection triggers pro-atherogenic inflammatory 1 responses in human coronary vessels

N. Eberhardt, M. G. Noval, R. Kaur, S. Sajja, L. Amadori, D. Das, B. Cilhoroz, O. J. Stewart, D. M. Fernandez, R. Shamailova, A. V. Guillen, S. Jangra, M. Schotsaert, M. Gildea, J. D. Newman, , C. Giannarelli

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

bioRxiv · Aug 14, 2023Immunology

MAVS signaling is required for clearance of chikungunya heart infection and prevention of chronic inflammation in vascular tissue

M. G. Noval, S. N. Spector, E. Bartnicki, F. Izzo, N. Narula, S. T. Yeung, P. Damani-Yokota, M. Z. Dewan, V. Mezzano, B. A. Rodriguez-Rodriguez, C. Loomis, K. M. Khanna, K. A. Stapleford

This study investigates CHIKV-induced heart disease using mouse models and human cells, showing MAVS signaling is critical for viral clearance and preventing chronic vascular inflammation.

bioRxiv · May 27, 2022 · PreprintMicrobiology

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production.

M. V. Rangel, N. Catanzaro, S. A. Thannickal, K. A. Crotty, M. G. Noval, K. E. E. Johnson, E. Ghedin, H. M. Lazear, K. A. Stapleford

This study identifies structurally conserved domains in flavivirus and alphavirus fusion glycoproteins that contribute to replication and infectious virion production, suggesting potential targets for broad-spectrum antivirals.

Journal of Virology · Jan 26, 2022Peer-reviewedMicrobiology

Emerging chikungunya virus variants at the E1-E1 inter-glycoprotein spike interface impact virus attachment and Inflammation

M. Rangel, N. McAllister, K. Dancel-Manning, M. G. Noval, L. Silva, K. A. Stapleford

This paper identifies emerging chikungunya virus E1 glycoprotein variants that enhance virus attachment, alter antibody neutralization, and increase inflammation in mice.

bioRxiv · Sep 13, 2021Microbiology

Combination of a Sindbis-SARS-CoV-2 spike vaccine and αOX40 antibody elicits protective immunity against SARS-CoV-2 induced disease and potentiates long-term SARS-CoV-2-specific humoral and T-cell immunity

A. Scaglione, S. Opp, A. Hurtado, C. Pampeno, Z. Lin, M. G. Noval, S. Thannickal, K. Stapleford, D. Meruelo

This paper combines a Sindbis-SARS-CoV-2 spike vaccine with αOX40 antibody to elicit long-term immunity and protect against SARS-CoV-2 disease in mice.

Frontiers in Immunology · Jul 29, 2021Peer-reviewedImmunology

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.

M. Venzon, L. Bernard-Raichon, J. Klein, J. E. Axelrad, C. Zhang, G. A. Hussey, A. P. Sullivan, A. Cassanovas-Massana, M. G. Noval, A. M. Valero-Jimenez, J. Gago, G. Putzel, A. Pironti, E. Wilder, Yale IMPACT Research Team, , J. Schluter

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

bioRxiv · Jul 15, 2021 · PreprintMicrobiology

Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice.

M. G. Noval, M. V. Rangel, K. E. Johnson, E. De Jesus, A. Gerber, S. Schuster, K. Cadwell, E. Ghedin, K. A. Stapleford

This study establishes a ZIKV transmission model in immunocompromised mice to investigate factors influencing viral evolution and DVG production.

Virus Evolution · Dec 11, 2020Peer-reviewedMicrobiology

High titers of multiple antibody isotypes against the SARS-CoV-2 spike receptor-binding domain and nucleoprotein associate with better neutralization.

M. G. Noval, M. E. Kaczmarek, A. Koide, B. A. Rodriguez-Rodriguez, P. Louie, T. Tada, T. Hattori, T. Panchenko, L. A. Romero, K. W. Teng, A. Bazley, M. de Vries, M. I. Samanovic, J. N. Weiser, I. Aifantis, , K. A. Stapleford

The paper assesses neutralization capacity and antibody titers against SARS-CoV-2 antigens in recovered healthcare workers, finding that high titers of multiple isotypes correlate with neutralization.

bioRxiv · Aug 15, 2020 · PreprintMicrobiology

Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination

M. G. Noval, B. A. Rodriguez-Rodriguez, M. V. Rangel, K. A. Stapleford

The paper identifies key glycoprotein residues in alphaviruses that regulate infectivity and dissemination through evolutionary analysis and functional studies.

bioRxiv · May 14, 2019Microbiology