K. A. Stapleford

The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity.

This study investigates how mutations in the CHIKV E1 glycoprotein's fusion loop and hinge affect virus infectivity in different cell types and hosts by altering E1-E2 dynamics.

SARS-CoV-2 infection triggers pro-atherogenic inflammatory 1 responses in human coronary vessels

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

The La Crosse virus class II fusion glycoprotein ij loop contributes to infectivity and cholesterol-dependent entry.

This study investigates the role of the La Crosse virus (LACV) class II fusion glycoprotein ij loop in infectivity and cholesterol-dependent entry, showing that specific residues are critical for virus function.

MAVS signaling is required for clearance of chikungunya heart infection and prevention of chronic inflammation in vascular tissue

This study investigates CHIKV-induced heart disease using mouse models and human cells, showing MAVS signaling is critical for viral clearance and preventing chronic vascular inflammation.

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production.

This study identifies structurally conserved domains in flavivirus and alphavirus fusion glycoproteins that contribute to replication and infectious virion production, suggesting potential targets for broad-spectrum antivirals.

Emerging chikungunya virus variants at the E1-E1 inter-glycoprotein spike interface impact virus attachment and Inflammation

This paper identifies emerging chikungunya virus E1 glycoprotein variants that enhance virus attachment, alter antibody neutralization, and increase inflammation in mice.

Two-dimensional multiplexed assay for rapid and deep SARS-CoV-2 serology profiling and for machine learning prediction of neutralization capacity

This paper introduces a 2D-MBBA assay for SARS-CoV-2 serology profiling and uses machine learning to predict neutralization capacity from antibody profiles.

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice.

This study establishes a ZIKV transmission model in immunocompromised mice to investigate factors influencing viral evolution and DVG production.

A soluble ACE2 microbody protein fused to a single immunoglobulin Fc domain is a potent inhibitor of SARS-CoV-2 infection in cell culture

The paper describes a modified soluble ACE2 protein that effectively inhibits SARS-CoV-2 infection in cell culture with higher potency than previous versions.

High titers of multiple antibody isotypes against the SARS-CoV-2 spike receptor-binding domain and nucleoprotein associate with better neutralization.

The paper assesses neutralization capacity and antibody titers against SARS-CoV-2 antigens in recovered healthcare workers, finding that high titers of multiple isotypes correlate with neutralization.

Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination

The paper identifies key glycoprotein residues in alphaviruses that regulate infectivity and dissemination through evolutionary analysis and functional studies.