Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production.
M. V. Rangel, N. Catanzaro, S. A. Thannickal, K. A. Crotty, M. G. Noval, K. E. E. Johnson, E. Ghedin, H. M. Lazear, K. A. Stapleford
This study identifies structurally conserved domains in flavivirus and alphavirus fusion glycoproteins that contribute to replication and infectious virion production, suggesting potential targets for broad-spectrum antivirals.
Journal of Virology · Jan 26, 2022Peer-reviewedMicrobiology