Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma
R. Joulia, F. Puttur, H. Stölting, L. J. Entwistle, A. Voitovich, M. Al-Sahaf, K. Bonner, E. Scotney, P. Molyneaux, R. J. Hewitt, S. A. Walker, L. L. Yates, S. Saglani, C. M. Lloyd
This study shows that mast cell activation in neonatal mice disrupts endothelial-pericyte interactions in the lungs, leading to vascular remodelling associated with allergic asthma.
bioRxiv · Mar 7, 2023Immunology