L. M. Carlin

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

Multimodal decoding of human liver regeneration

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

This study shows that changes in the extracellular matrix in IPF affect KRT5+ basal cell migration and function, contributing to lung fibrosis.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

Asbestos accelerates disease onset in a genetic model of Malignant Pleural Mesothelioma

This study shows asbestos accelerates mesothelioma onset and increases tumor burden in a genetic mouse model, with increased macrophage infiltration, but macrophage suppression did not improve survival.

The mouse lung early cellular innate immune response is not sufficient to control fungal infection with Cryptococcus neoformans

This study uses an ex vivo mouse lung model to show that innate immune cells cannot control Cryptococcus neoformans infection and provide an intracellular niche for fungal growth.