R. Lennon

Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

This study shows that changes in the extracellular matrix in IPF affect KRT5+ basal cell migration and function, contributing to lung fibrosis.

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

The paper develops a pipeline to identify BM-associated proteins, finds new regulators, and links BM genes to human disease.

A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish

This paper develops a transgenic zebrafish reporter to measure proteinuria, demonstrating its utility in detecting kidney disease models and drug responses.

Kidney organoids: A system to study human basement membrane assembly in health and disease

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

Ongoing exposure to peritoneal dialysis fluid alters resident peritoneal macrophage phenotype and activation propensity

This study shows that long-term exposure to peritoneal dialysis fluid changes peritoneal macrophage function, increasing inflammation and reducing tissue resident cell survival in mice.