C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases
S. A. Zwarthoff, K. Widmer, A. Kuipers, J. Strasser, M. Ruyken, P. Aerts, C. J. C. de Haas, D. Ugurlar, G. Vidarsson, J. van Strijp, P. Gros, P. Parren, K. P. M. van Kessel, J. Preiner, F. J. Beurskens, , S. H. M. Rooijakkers
This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.
bioRxiv · Feb 8, 2021Immunology