Mutant-selective Degradation by BRAF-targeting PROTACs
S. Alabi, S. Jaime-Figueroa, Z. Yao, Y. Gao, J. Hines, K. . T. G. Samarasinghe, L. Vogt, N. Rosen, C. M. Crews
This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.
bioRxiv · Aug 10, 2020Cancer Biology