A. Erez

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

This study shows antibiotics damage the colonic mucus barrier independently of microbiota, leading to bacterial penetration and IBD exacerbation.

Optimal antimicrobial response to a changing microbial background at a mucus interface

The paper develops a minimal model to explain how hosts optimize antimicrobial defense at the intestinal mucus interface by integrating signals from bulk microbiota and segmented filamentous bacteria.

Grow now, pay later: when should a bacterium go into debt?

The paper introduces a mathematical model of microbial 'growth debt' and shows how debtors can coexist with non-debtors under certain conditions, with implications for antibiotic resistance.

Diversity loss in microbial ecosystems undergoing gradual environmental changes

This study models how gradual environmental changes impact microbial ecosystems, showing that diversity loss leads to slowed dynamics and potential response lags in diverse ecosystems.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Sex biases in cancer and autoimmune disease incidence are strongly positively correlated with mitochondrial gene expression across human tissues

Using a recently approved tumor mutational burden biomarker to stratify patients for immunotherapy may introduce a sex bias

The paper investigates if using a high tumor mutational burden (TMB) threshold for immunotherapy selection introduces sex bias, finding significant bias in melanoma but not in other cancers.

Quantifying the dynamics of hematopoiesis by in vivo IdU pulse-chase, mass cytometry and mathematical modeling

The paper develops a method combining IdU pulse-chase, mass cytometry, and mathematical modeling to quantify hematopoietic differentiation dynamics in mice.

Modeling of cytometry data in logarithmic space: when is a bimodal distribution not bimodal?

The paper shows that bimodal distributions in logarithmic cytometry data may reflect unimodal distributions in linear scale and introduces a test to detect this mismatch.