Author

S. Brich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:organoid / primary culture· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Podesta· 2 shared D. Baratti· 2 shared F. Pisati· 2 shared G. Pruneri· 2 shared L. Varinelli· 2 shared M. Chighizola· 2 shared M. Deraco· 2 shared M. Gariboldi· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

A. Podesta

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The nanomechanical fingerprint of colorectal-derived peritoneal metastasis

E. Lorenc, L. Varinelli, M. Chighizola, S. Brich, F. Pisati, M. Guaglio, D. Baratti, M. Deraco, M. Gariboldi, A. Podesta

This study investigates the mechanical properties of extracellular matrix in colorectal cancer peritoneal metastases using AFM, finding ECM stiffening and spatial heterogeneity linked to cancer progression and clinical factors.

bioRxiv · Aug 17, 2022 · PreprintBiophysics

Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

A. Anichini, A. Molla, G. Nicolini, V. E. Perotti, F. Sgambelluri, A. Covre, C. Fazio, M. F. Lofiego, A. M. Di Giacomo, S. Coral, A. Manca, M. C. Sini, M. Pisano, T. Noviello, F. Caruso, , R. Mortarini

This paper identifies immune-related gene signatures induced by four epigenetic inhibitors in melanoma cells, finding that guadecitabine most strongly upregulates immune-related genes and activates innate immunity pathways.

bioRxiv · Apr 13, 2022Immunology

Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases

L. Varinelli, M. Guaglio, S. Brich, S. Zanutto, A. Belfiore, F. Zanardi, F. Iannelli, A. Oldani, E. Costa, M. Chighizola, S. P. Minardi, S. Fortuzzi, M. Filugelli, G. Garzone, F. Pisati, , M. Gariboldi

The paper develops 3D organoid cultures using decellularized ECM from colorectal peritoneal metastases to model the metastatic niche and assess chemotherapy response.

bioRxiv · Jul 15, 2021 · PreprintCancer Biology