S. Casas-Tinto

Novel genetic model of pediatric Diffuse Intrinsic Pontine Glioma in Drosophila melanogaster

This paper develops a Drosophila melanogaster model of DIPG by overexpressing H3K27 and Myc in glial cells, revealing distinct molecular features compared to glioblastoma.

Modeling invasion patterns in the glioblastoma battlefield

The paper models glioblastoma invasion patterns using in vivo Drosophila experiments and mathematical models to predict tumor progression.

Small heat shock proteins determine synapse number and neuronal activity during development

The paper identifies two small heat shock proteins, sHSP23 and sHSP26, and their regulatory gene Pinkman as critical for synapse number and neuronal activity during Drosophila development.

Cell to cell communication is an early event in glioblastoma

This study identifies early cell-to-cell communication as a key driver in glioblastoma progression through Wg signaling and JNK pathway activation.

Wingless promotes JNK/MMPs positive feedback loop mediate tumour microtubes expansion, glioma progression and neurodegeneration

The paper identifies a Wg/JNK/MMPs positive feedback loop driving tumour microtubes expansion, glioma progression, and neurodegeneration in a Drosophila GB model.

WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration

This study shows glioblastoma cells deplete Wnt signaling from neurons, leading to tumor growth and neurodegeneration in Drosophila and human xenograft models.

Troponin-I localizes selected apico-basal cell polarity signals

This study shows that Drosophila Troponin I localizes specific apico-basal polarity signals in different cell types, revealing new mechanisms for cell polarity regulation.