F. Winkler

Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanoma

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

This paper introduces Deep3P, a three-photon microscopy and AI analysis method that enables deep intravital imaging of glioblastoma in mouse brains, revealing new insights into tumor invasion routes and white matter disruption.

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration

This study shows glioblastoma cells deplete Wnt signaling from neurons, leading to tumor growth and neurodegeneration in Drosophila and human xenograft models.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.