V. Venkataramani

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanoma

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

This paper introduces Deep3P, a three-photon microscopy and AI analysis method that enables deep intravital imaging of glioblastoma in mouse brains, revealing new insights into tumor invasion routes and white matter disruption.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

A crosstalk between hepcidin and IRE/IRP pathways controls ferroportinexpression and determines serum iron levels in mice

This study shows that hepcidin and IRE/IRP pathways interact to regulate ferroportin expression and serum iron levels in mice, with iron affecting hepcidin's ability to induce hypoferremia.

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration

This study shows glioblastoma cells deplete Wnt signaling from neurons, leading to tumor growth and neurodegeneration in Drosophila and human xenograft models.