Author

S. Castellano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Gomez-Castaneda· 2 shared A. Eddaoudi· 1 shared A. Giustacchini· 1 shared A. Guvenel· 1 shared A. M. Andres· 1 shared B. Bea Mascato· 1 shared C. J. Tape· 1 shared D. Moulding· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

E. Gomez-Castaneda

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes

B. Bea Mascato, E. Gomez-Castaneda, Y. E. Sanchez-Corrales, S. Castellano, D. Valverde

This study shows that ALMS1 depletion disrupts TGF-β pathway cross-signalling and affects extracellular matrix and lipid metabolism in fibroblasts.

bioRxiv · Nov 2, 2022Cell Biology

Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth while preserving stem cell characteristics

V. Jayarajan, G. T. Hall, T. Xenakis, N. Bulstrode, D. Moulding, S. Castellano, W.-L. Di

Short-term ROCKi treatment accelerates keratinocyte growth without compromising stem cell characteristics, suggesting a safe method for clinical applications.

bioRxiv · Jun 28, 2022Cell Biology

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

I. M. Michelozzi, E. Gomez-Castaneda, R. V. C. Pohle, F. Cardoso-Rodriguez, J. Sufi, P. Puigdevall-Costa, M. Subraniyam, E. Kirtsios, A. Eddaoudi, S. W. Wu, A. Guvenel, J. Fisher, S. Ghorashian, M. A. Pule, C. J. Tape, , A. Giustacchini

The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.

bioRxiv · Sep 22, 2020Cancer Biology

Evidence that viruses, particularly SIV, drove genetic adaptation in natural populations of eastern chimpanzees

J. M. Schmidt, M. de Manuel, T. Marques-Bonet, S. Castellano, A. M. Andres

The paper identifies genetic adaptations in eastern chimpanzees linked to SIV infection, showing distinct immune-related gene differentiation compared to central chimpanzees.

bioRxiv · Mar 21, 2019Evolutionary Biology