C. J. Tape

SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.

A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation

The paper maps how oncogenic mutations and microenvironmental signals co-regulate colonic stem cell fate through single-cell analysis of organoid cultures.

OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity

OPS-γδ cells, engineered to secrete opsonins and stabilized IL15, show enhanced cytotoxicity and bystander activation for solid tumor control.

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.

Single-Cell Signalling Analysis of Heterocellular Organoids

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

Conduit integrity is compromised during acute lymph node expansion

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.