Author

J. Sufi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell-cell communication· 3 Assay:proteomics· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. J. Tape· 6 shared X. Qin· 4 shared P. Vlckova· 3 shared A. Eddaoudi· 1 shared A. Giustacchini· 1 shared A. Guvenel· 1 shared A. Tong· 1 shared B. C. Jones· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersCancer Biology

C. J. Tape

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Author profile →

6 papers

Recent·Most cited

Human Gastric Multi-Regional Assembloids Favour Functional Parietal Maturation and Allow Modelling of Antral Foveolar Hyperplasia

B. C. Jones, G. Benedetti, G. Cala, L. Tullie, I. Simcock, R. Lutman, M. Balys, R. Amiri, J. Sufi, O. Arthurs, S. Eaton, G. Anderson, N. Elvassore, V. S. Li, K. D. Jones, , P. De Coppi

The paper develops multi-regional gastric assembloids from patient-derived organoids to model parietal cell maturation and antral foveolar hyperplasia in genetic disorders.

bioRxiv · Jul 8, 2024 · PreprintCell Biology

SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis

J. W. Opzoomer, R. O'Sullivan, J. Sufi, R. R. Madsen, X. Qin, E. Basiarz, C. J. Tape

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation

X. Qin, F. C. Rodriguez, J. Sufi, P. Vlckova, J. Claus, C. J. Tape

The paper maps how oncogenic mutations and microenvironmental signals co-regulate colonic stem cell fate through single-cell analysis of organoid cultures.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

I. M. Michelozzi, E. Gomez-Castaneda, R. V. C. Pohle, F. Cardoso-Rodriguez, J. Sufi, P. Puigdevall-Costa, M. Subraniyam, E. Kirtsios, A. Eddaoudi, S. W. Wu, A. Guvenel, J. Fisher, S. Ghorashian, M. A. Pule, C. J. Tape, , A. Giustacchini

The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.

bioRxiv · Sep 22, 2020Cancer Biology

Single-Cell Signalling Analysis of Heterocellular Organoids

X. Qin, J. Sufi, P. Vlckova, P. Kyriakidou, S. E. Acton, V. S. W. Li, M. Nitz, C. J. Tape

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

bioRxiv · Nov 11, 2019Cell Biology