S. Chinnathambi

EGCG modulates nuclear formaldehyde-induced Tau phosphorylation in Neuronal cells

This study shows EGCG reduces formaldehyde-induced nuclear Tau phosphorylation and CDK5 levels in neuronal cells and a Drosophila model.

A green tea polyphenol Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

This study shows that EGCG inhibits Tau glycation and rescues cytoskeletal damage in neuroblastoma cells induced by methylglyoxal.

Photo-excited Toluidine Blue disaggregates the Repeat Tau and modulates Cytoskeletal structure in neuronal cells

This study shows that Toluidine Blue inhibits Tau aggregation and photo-excited TB disaggregates pre-formed Tau fibrils while modulating cytoskeletal structures in neuronal cells.

Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology

This study investigates melatonin's effect on Tau aggregation and cell surface morphology in neuro2a and N9 cell lines, finding it reduces higher order oligomers and maintains membrane topology.

Melatonin reduces GSK3β expression and tau phosphorylation via Nrf2 nuclear translocation

This study shows melatonin reduces GSK3β expression and tau phosphorylation, mitigates neuronal cytotoxicity, and combats oxidative stress in Alzheimer's disease models.

Baicalein suppresses Tau fibrillization by sequestering oligomers

This study investigates Baicalein's ability to inhibit Tau aggregation and dissolve preformed oligomers and fibrils, suggesting its potential as a therapeutic for Alzheimer's disease.

Modulation of Actin network and Tau phosphorylation by HDAC6 ZnF UBP domain

This study investigates how the HDAC6 ZnF UBP domain affects Tau phosphorylation, actin organization, and other cellular processes in neuronal cells.

Substrate deformations induce directed keratinocyte migration

This study shows keratinocytes respond to mechanical substrate deformations by migrating, with Rho/ROCK and NM II pathways being essential for this response.