Elevated levels of interleukin-27 in early life compromise protective immunity during neonatal sepsis
B. G. Seman, J. K. Vance, T. W. Rawson, M. R. Witt, A. B. Huckaby, J. M. Povroznik, S. D. Bradford, M. Barbier, C. M. Robinson
This study shows elevated IL-27 in neonates worsens sepsis outcomes by impairing bacterial control and promoting inflammation.
bioRxiv · Sep 20, 2019Immunology