C. M. Robinson

A viral-specific CD4+ T cell response protects female mice from Coxsackievirus B3 infection

This study shows that female mice develop a CD4+ T cell response to Coxsackievirus B3 that reduces mortality, while male mice do not.

Coxsackievirus B3 elicits a sex-specific CD8+ T cell response in female mice.

This study shows that Coxsackievirus B3 induces a sex-specific CD8+ T cell response in female mice, independent of inoculation route and type I interferon.

Testosterone promotes intestinal replication and dissemination of Coxsackievirus B3 in an oral inoculation mouse model

This study shows testosterone increases intestinal replication and dissemination of Coxsackievirus B3 in mice and alters the immune response to the virus.

Specific bacterial cell wall components influence the stability of Coxsackievirus B3

This study shows that specific gram-negative bacteria and their cell wall components enhance Coxsackievirus B3 infectivity and stability, while similar effects are not observed for poliovirus.

Neonatal granulocytic MDSCs possess phagocytic properties during bacterial infection.

This study shows human granulocytic MDSCs can phagocytose bacteria but are less efficient than monocytes, releasing DNA that affects bacterial viability but not monocyte function.

Elevated levels of interleukin-27 in early life compromise protective immunity during neonatal sepsis

This study shows elevated IL-27 in neonates worsens sepsis outcomes by impairing bacterial control and promoting inflammation.

Related enteric viruses have different requirements for host microbiota in mice

The paper shows that coxsackievirus B3 (CVB3) is more sensitive to antibiotic-induced microbiota depletion than poliovirus, suggesting differences in microbiota reliance among related enteric viruses.

Plaques formed by mutagenized viral populations have elevated co-infection frequencies

This study shows that multiple viruses can contribute to plaque formation, with co-infection frequencies increasing in highly mutagenized viral populations.