Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade
S. Dakhel, T. Ongaro, B. Gouyou, M. Matasci, A. Villa, D. Neri, S. Cazzamalli
This study shows that transient RIPK1 inhibition increases the tolerated dose of L19-TNF while preserving its antitumor effects and tumor targeting.
bioRxiv · Jul 30, 2019Pharmacology & Toxicology