B. Gouyou

Antibody-based delivery of Interleukin-9 to neovascular structures: therapeutic evaluation in cancer and arthritis

This study evaluates the therapeutic potential of IL9 delivered via antibody-based fusion proteins in cancer and arthritis models, finding modest anti-tumor activity but no benefit in arthritis.

Sortase-mediated site-specific modification of interleukin-2 for the generation of a tumor targeting acetazolamide-cytokine conjugate

This paper develops a tumor-targeting cytokine conjugate using Sortase A-mediated site-specific modification of interleukin-2 with acetazolamide, targeting carbonic anhydrase IX.

A novel fully-human potency-matched dual cytokine-antibody fusion protein targets carbonic anhydrase IX in renal cell carcinomas

This paper describes the development and characterization of a dual cytokine-antibody fusion protein targeting carbonic anhydrase IX in renal cell carcinomas, showing tumor localization and growth inhibition.

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

This study shows that transient RIPK1 inhibition increases the tolerated dose of L19-TNF while preserving its antitumor effects and tumor targeting.

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune check-point inhibitors

This paper describes a fusion protein that delivers interleukin-12 to tumors, enhancing NK and CD8+ T cell activity and synergizing with checkpoint inhibitors.