Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
J. S. Dolina, J. Lee, S. E. Brightman, S. McArdle, S. M. Hall, R. R. Thota, M. Lanka, A. L. R. Premlal, J. A. Greenbaum, E. E. W. Cohen, B. Peters, S. P. Schoenberger
This study shows that combining CD4+/CD8+ T cell neoantigen vaccination with immune checkpoint blockade overcomes resistance and enables tumor regression in low TMB cancers.
bioRxiv · May 6, 2023 · PreprintImmunology