Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave
L. A. Hohsfield, A. R. Najafi, Y. Ghorbanian, N. Soni, J. Crapser, D. X. Figueroa Velez, S. Jiang, S. E. Royer, S. J. Kim, A. Anderson, S. P. Gandhi, A. Mortazavi, M. A. Inlay, K. N. Green
The paper depletes adult microglia using CSF1R inhibition and shows that subventricular zone/white matter myeloid cells dynamically repopulate the brain, exhibiting distinct phenotypes from endogenous microglia.
bioRxiv · Feb 17, 2021Immunology