S. Guang

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

Compartmentalized localization of perinuclear proteins within germ granules in C. elegans

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

Nucleolar stress induced the formation of a nucleolar stress body via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans

The paper identifies a new subnuclear organelle called the nucleolar stress body (NoSB) in C. elegans, formed through the NOSR-1/NUMR-1 axis in response to nucleolar stress.

Germ granule compartments coordinate specialized small RNA production

The paper identifies a new subcompartment in C. elegans germ granules that facilitates specialized small RNA production, essential for fertility and RNAi response.

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin

This study shows early-life thermal stress increases TSP-1 in C. elegans, leading to longevity and resilience through tetraspanin web formation.

rRNA intermediates coordinate the multilayered nucleolar phase transition in C. elegans

This study identifies two types of nucleoli in C. elegans and shows that rRNA processing factors regulate their structure and dynamics.