S. Harms

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

Spike protein disulfide disruption as a potential treatment for SARS-CoV-2

This paper shows that reducing disulfide bonds in the SARS-CoV-2 Spike protein inhibits viral entry and replication, suggesting a potential antiviral treatment.