Author

R. Melnyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Tam· 2 shared C. M. Pike· 1 shared C. M. Theriot· 1 shared D. Falzarano· 1 shared E. Mei· 1 shared E. Rujas· 1 shared G. L. Beilhartz· 1 shared H. Liang· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

J. Tam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhanced delivery of protein therapeutics with a diphtheria toxin-like platform that evades pre-existing neutralizing immunity

S. Gill, S. Sugiman-Marangos, G. L. Beilhartz, E. Mei, M. Taipale, R. Melnyk

This paper identifies a diphtheria toxin homolog from Austwickia chelonae that evades pre-existing anti-DT antibodies and shows improved cargo delivery compared to diphtheria toxin.

bioRxiv · Apr 2, 2024 · PreprintBiochemistry

Tauroursodeoxycholic acid inhibits Clostridioides difficile toxin induced apoptosis

C. M. Pike, J. Tam, R. Melnyk, C. M. Theriot

This study shows that taurine-conjugated ursodeoxycholic acid (TUDCA) inhibits C. difficile toxin-induced apoptosis in Caco-2 cells, while unconjugated UDCA does not, highlighting the importance of bile acid conjugation in CDI therapy.

bioRxiv · Apr 13, 2022 · PreprintMicrobiology

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

S. Icho, E. Rujas, K. Muthuraman, J. Tam, H. Liang, S. Harms, M. Liao, D. Falzarano, J.-P. Julien, R. Melnyk

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

bioRxiv · Mar 11, 2022Cell Biology