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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
M. Uckelmann, V. Levina, C. Taveneau, X. H. Ng, V. Pandey, J. Martinez, S. Mendiratta, J. Houx, M. Boudes, H. Venugopal, S. Trepout, Q. Zhang, S. Flanigan, M. Li, E. Sierecki, , C. Davidovich
This study uses cryo-electron tomography to reveal that PRC1-CBX8 condensates are porous and dynamic, challenging the notion of rigid chromatin compaction in gene repression.
bioRxiv · May 8, 2023Biophysics
C. F. Dickson, S. Hertel, J. Ruan, N. Ariotti, A. Tuckwell, N. Li, S. Al-Izzi, E. Sierecki, Y. Gambin, R. G. Morris, G. J. Towers, T. Boecking, D. A. Jacques
This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.
bioRxiv · Mar 23, 2023 · PreprintBiochemistry
A. Leitao, P. Rudolffi Soto, A. Chappard, A. Bhumkar, D. J. B. Hunter, E. Sierecki, Y. Gambin
This study maps protein interactions with different -SYN aggregation species, revealing selectivity in recruitment of LB components during aggregation.
bioRxiv · Jan 29, 2021Biochemistry
D. Lau, J. C. Walsh, C. F. Dickson, A. Tuckwell, J. H. Stear, D. J. B. Hunter, A. Bhumkar, V. Shah, S. G. Turville, E. Sierecki, Y. Gambin, D. A. Jacques, T. Böcking
This paper develops a fluorescence fluctuation spectroscopy method to rapidly screen HIV-1 capsid interactors by detecting binding events in solution.
bioRxiv · Nov 13, 2020Biophysics
A. J. McCann, J. Lou, M. Moustaqil, A. Blum, F. Fontaine, H. Liu, W. Luu, P. Koopman, E. Sierecki, Y. Gambin, F. A. Meunier, Z. Liu, E. Hinde, M. Francois
This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.
bioRxiv · Nov 11, 2020Cell Biology
J. Rae, C. Ferguson, N. Ariotti, R. Webb, H.-H. Cheng, J. Mead, J. Riches, D. Hunter, N. Martel, J. Baltos, A. Christopoulos, N. Bryce, M. Cagigas, S. Fonseka, E. Hardeman, , R. G. Parton
APEX-Gold converts APEX reaction products into silver/gold particles for improved EM detection of tagged proteins.
bioRxiv · Oct 6, 2020 · PreprintCell Biology
B. Meyer, J. Chiaravalli, S. Gellenoncourt, P. Brownridge, D. P. Bryne, L. A. Daly, A. Grauslys, M. Walter, F. Agou, L. A. Chakrabarti, C. S. Craik, C. E. Eyers, P. A. Eyers, Y. Gambin, A. R. Jones, , E. Emmott
This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.
bioRxiv · Sep 16, 2020Microbiology
R. G. Parton, K.-A. McMahon, D. A. Stroud, Y. Gambin, V. Tillu, M. Bastiani, E. Sierecki, M. Polinkovsky, T. E. Hall, G. A. Gomez, Y. Wu, M.-O. Parat, N. Martel, H. P. Lo, K. k. Khanna, , M. Ryan
This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.
bioRxiv · Jul 26, 2020Cancer Biology
N. Ariotti, Y. Wu, S. Okano, Y. Gambin, J. Follett, J. Rae, C. Ferguson, R. D. Teasdale, K. Alexandrov, F. A. Meunier, M. M. Hill, R. G. Parton
The paper identifies an inverted Cav1 topology in exosomes secreted by prostate cancer cells, revealing a non-canonical autophagy pathway involved in disease progression.
bioRxiv · Mar 19, 2020Cell Biology
M. Steain, M. O. D. G. Baker, C. L. L. Pham, Y. Gambin, E. Sierecki, B. P. McSharry, S. Avdic, B. Slobedman, M. Sunde, A. Abendroth
This paper identifies a viral RHIM in VZV ORF20 that forms amyloid complexes with ZBP1 to inhibit apoptosis during infection.
bioRxiv · Mar 12, 2020Microbiology
S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock
This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.
bioRxiv · Mar 17, 2019 · PreprintBiochemistry