Author

S. J. Aitken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Feig· 2 shared D. T. Odom· 2 shared F. Connor· 2 shared M. Lukk· 2 shared T. F. Rayner· 2 shared A. D. Yates· 1 shared A. Ewing· 1 shared A. Garcia-Gimenez· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. Feig

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LGR5 targeting molecules as therapeutic agents for multiple cancer types

H.-C. Chen, N. Mueller, K. Stott, E. Rivers, C. Kapeni, C. M. Sauer, F. Beke, S. Walsh, N. Ashman, L. M. O'Brien, A. R. Fard, A. Godsinia, F. Joud, O. Giger, I. Zlobec, , M. de la Roche

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

bioRxiv · Sep 1, 2022 · PreprintCell Biology

Pervasive lesion segregation shapes cancer genome evolution

S. J. Aitken, C. J. Anderson, F. Connor, O. Pich, V. Sundaram, C. Feig, T. F. Rayner, M. Lukk, S. Aitken, J. Luft, E. Kentepozidou, C. Arnedo-Pac, S. Beentjes, S. E. Davies, R. M. Drews, , M. S. Taylor

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

bioRxiv · Dec 8, 2019Cancer Biology

Mutational landscape of a chemically-induced mouse model of liver cancer

F. Connor, T. F. Rayner, C. Feig, S. J. Aitken, M. Lukk, D. T. Odom

This study characterizes the mutational landscape of liver tumors in a chemically-induced mouse model, revealing distinct mutation patterns and potential oncogenic drivers.

bioRxiv · Jan 4, 2018Cancer Biology