Author

M. de la Roche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Kapeni· 2 shared F. Beke· 2 shared H.-C. Chen· 2 shared L. M. O'Brien· 2 shared A. D. Jenks· 1 shared A. Garcia-Gimenez· 1 shared A. Godsinia· 1 shared A. R. Fard· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

C. Kapeni

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LGR5 targeting molecules as therapeutic agents for multiple cancer types

H.-C. Chen, N. Mueller, K. Stott, E. Rivers, C. Kapeni, C. M. Sauer, F. Beke, S. Walsh, N. Ashman, L. M. O'Brien, A. R. Fard, A. Godsinia, F. Joud, O. Giger, I. Zlobec, , M. de la Roche

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

bioRxiv · Sep 1, 2022 · PreprintCell Biology

Non-canonical Hedgehog signaling through L-type voltage gated Ca2+ channels controls CD8+ T cell killing

J. Hanna, C. Kapeni, L. O'Brien, V. Carbonaro, F. Beke, C. Chilamakuri, M. de la Roche

This study identifies L-type voltage gated Ca2+ channels as essential for Hedgehog signaling in CD8+ T cells, which is critical for their cytotoxic function.

bioRxiv · Mar 1, 2021 · PreprintImmunology

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation

H. Rannikmae, S. Peel, S. Barry, I. K. Sur, J. Taipale, T. Senda, M. de la Roche

This study identifies three distinct effector pathways regulated by Apc in murine intestinal epithelia, each contributing to normal tissue homeostasis and tumorigenesis when disrupted by oncogenic Apc mutations.

bioRxiv · Jun 10, 2020Cell Biology

Altered composition of the γδ T cell pool in lymph nodes during ageing enhances tumour growth

H.-C. Chen, N. Eling, C. P. Martinez-Jimenez, L. M. O'Brien, J. C. Marioni, D. T. Odom, M. de la Roche

This study shows that ageing alters the composition of γδ T cells in lymph nodes, promoting tumour growth in mice.

bioRxiv · Nov 27, 2018 · PreprintImmunology

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

A. D. Jenks, S. Vyse, J. P. Wong, D. Keller, T. Burgoyne, A. Shoemark, M. de la Roche, A. Tsalikis, M. Michaelis, J. Cinatl, P. H. Huang, B. E. Tanos

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.

bioRxiv · Aug 25, 2017Cell Biology