C. J. Anderson

Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology

This study shows that allopregnanolone in the prefrontal cortex mediates stress-induced worsening of tics in a mouse model of Tourette syndrome.

A microbiota-derived metabolite instructs peripheral efferocytosis

This study identifies butyrate, a microbiota-derived metabolite, as a regulator of peripheral efferocytosis, showing its ability to restore impaired phagocytic clearance in antibiotic-treated mice.

The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in Streptococcus pyogenes

This study investigates how Rgg2/3 quorum sensing affects the transcriptome and proteome of Streptococcus pyogenes under induced or disrupted conditions, revealing stress responses linked to the stringent response.

Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection

This study shows that granzymes A and B use distinct cell death pathways to protect against intestinal Salmonella infection by balancing bacterial growth and translocation.

Influence of the artificial sodium saccharin sweetener Sucram(R) on the microbial community composition in the rumen content and attached to the rumen epithelium in dairy cattle: A pilot study

This study examines the impact of Sucram(R) on rumen microbial communities in dairy cattle, finding significant changes in epithelial microbiota but not overall community structure.

Pervasive lesion segregation shapes cancer genome evolution

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

Preclinical immunoPET imaging of glioblastoma-infiltrating myeloid cells using Zirconium-89-labeled anti-CD11b antibody

This paper evaluates 89Zr-labeled anti-CD11b antibody for non-invasive immunoPET imaging of TAMCs in a glioblastoma mouse model, showing specific tumor uptake and validating CD11b expression.

Structural basis for activation of Dot1L methyltransferase on the nucleosome by histone H2BK120 ubiquitylation

This study determines the cryo-EM structure of Dot1L bound to a ubiquitylated H2BK120 nucleosome, revealing how H2BK120 ubiquitylation activates Dot1L methylation of H3K79.