Material aging causes centrosome weakening and disassembly during mitotic exit
M. Mittasch, V. M. Tran, M. U. Rios, A. W. Fritsch, S. J. Enos, B. Ferreira Gomes, A. Bond, M. Kreysing, J. B. Woodruff
The paper investigates how centrosome material properties change during mitotic exit in C. elegans embryos, finding that PLK-1 and SPD-2 confer strength and ductility before anaphase, which is lost as centrosomes transition to a brittle state.
bioRxiv · Dec 5, 2019Cell Biology