Author

J. B. Woodruff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:C. elegans· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. U. Rios· 4 shared B. D. Ryder· 2 shared B. Ferreira Gomes· 2 shared Łukasz A. Joachimiak· 2 shared N. Familiari· 2 shared S. J. Enos· 2 shared V. M. Tran· 2 shared A. A. Hyman· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

M. U. Rios

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Native molecular architectures of centrosomes in C. elegans embryos

F. Tollervey, M. U. Rios, E. Zagoriy, J. B. Woodruff, J. Mahamid

The paper uses cryo-electron tomography to visualize centrosomes in C. elegans embryos, revealing structural features and differences in microtubule organization during the cell cycle.

bioRxiv · Apr 3, 2024 · PreprintCell Biology

A central helical hairpin in SPD-5 enables centrosome strength and assembly

M. U. Rios, B. D. Ryder, N. Familiari, Łukasz A. Joachimiak, J. B. Woodruff

The paper identifies a helical hairpin in SPD-5 critical for centrosome assembly and strength, showing mutations disrupt PCM formation and resilience to microtubule forces.

bioRxiv · May 16, 2023 · PreprintCell Biology

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength

M. U. Rios, M. A. Bagnucka, B. D. Ryder, B. F. Gomes, N. Familiari, K. Yaguchi, M. Amato, Łukasz A. Joachimiak, J. B. Woodruff

The paper identifies coiled-coil interactions in SPD-5 that enable centrosome assembly and strength by resisting microtubule-mediated forces.

bioRxiv · May 15, 2023 · PreprintCell Biology

Interactions between TULP3 tubby domain cargo site and ARL13B amphipathic helix promote lipidated protein transport to cilia

V. R. Palicharla, S.-h. Hwang, B. N. Somatilaka, H. B. Badgandi, E. Legue, V. M. Tran, J. B. Woodruff, K. F. Liem, S. Mukhopadhyay

This study identifies how TULP3 interacts with ARL13B to transport lipidated and transmembrane proteins to cilia through specific binding motifs.

bioRxiv · May 25, 2021Cell Biology

Material aging causes centrosome weakening and disassembly during mitotic exit

M. Mittasch, V. M. Tran, M. U. Rios, A. W. Fritsch, S. J. Enos, B. Ferreira Gomes, A. Bond, M. Kreysing, J. B. Woodruff

The paper investigates how centrosome material properties change during mitotic exit in C. elegans embryos, finding that PLK-1 and SPD-2 confer strength and ductility before anaphase, which is lost as centrosomes transition to a brittle state.

bioRxiv · Dec 5, 2019Cell Biology

FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing

R. P. Lemaitre, A. Bogdanova, B. Borgonovo, J. B. Woodruff, D. N. Drechsel

FlexiBAC simplifies baculovirus production and enables proteolytic maturation of secreted proteins, demonstrating effectiveness in producing active TGF-β family growth factors.

bioRxiv · Nov 14, 2018Biochemistry

Phosphatase PP2A and microtubule pulling forces disassemble centrosomes during mitotic exit

S. J. Enos, M. Dressler, B. Ferreira Gomes, A. A. Hyman, J. B. Woodruff

The paper identifies PP2A and microtubule pulling forces as key factors in PCM disassembly during mitotic exit in C. elegans embryos.

bioRxiv · Sep 12, 2017Cell Biology