Author

S. J. Koo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Saghatelian· 1 shared B. Cravatt· 1 shared B. Ghosh· 1 shared B. Melillo· 1 shared C. Reinhardt· 1 shared D. Malkov· 1 shared D. Ogasawara· 1 shared D. Seynaeve· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Saghatelian

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2 papers

Recent·Most cited

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry

Tales of 1,008 Small Molecules: Phenomic Profiling through Live-cell Imaging in a Panel of Reporter Cell Lines

M. J. Cox, S. Jaensch, J. Van de Waeter, L. Cougnaud, D. Seynaeve, S. Benalla, S. J. Koo, I. Van Den Wyngaert, J.-M. Neefs, D. Malkov, M. Bittremieux, M. Steemans, P. J. Peeters, J. K. Wegner, H. Ceulemans, , H. W. H. Göhlmann

The paper uses live-cell imaging of reporter cell lines to profile 1,008 compounds, identifying their mechanisms of action with high accuracy.

bioRxiv · Mar 13, 2020Pharmacology & Toxicology