Author

S. J. Won

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Melillo· 4 shared E. Njomen· 3 shared B. Cravatt· 2 shared B. F. Cravatt· 2 shared D. Ogasawara· 2 shared H. Li· 2 shared K. DeMeester· 2 shared S. Schreiber· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

B. Melillo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Redirecting the pioneering function of FOXA1 with covalent small molecules

S. J. Won, Y. Zhang, C. J. Reinhardt, N. S. MacRae, K. E. DeMeester, E. Njomen, L. M. Hargis, J. R. Remsberg, B. Melillo, B. F. Cravatt, M. A. Erb

This study identifies covalent small molecules that bind FOXA1, altering its chromatin remodeling activity in prostate cancer cells.

bioRxiv · Mar 21, 2024Biochemistry

Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

D. Ogasawara, D. Konrad, Z. Y. Tan, K. Carey, J. Luo, S. J. Won, H. Li, T. Carter, K. DeMeester, E. Njomen, S. Schreiber, R. Xavier, B. Melillo, B. Cravatt

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

bioRxiv · Feb 27, 2024Biochemistry

Expanding the ligandable proteome by paralog hopping with covalent probes

Y. Zhang, Z. Liu, M. Hirschi, O. Brodsky, E. Johnson, S. J. Won, A. Nagata, M. D. Petroski, J. D. Majmudar, S. Niessen, T. VanArsdale, A. M. Gilbert, M. M. Hayward, A. E. Stewart, A. R. Nager, , B. F. Cravatt

The paper uses covalent probes and paralog hopping to identify ligandable pockets in proteins lacking cysteines, demonstrating a method to expand the ligandable proteome.

bioRxiv · Jan 18, 2024 · PreprintBiochemistry

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry