Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain
Y. Zhang, C. P. Riedstra, S. Wang, S. Patel, T. Bald, P. Kumar, A. Rohani, D. F. Kashatus, S. J. Moschos, A. C. Dudley
This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.
bioRxiv · Jul 15, 2022 · PreprintCancer Biology