Author

S. J. Piersma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

W. M. Yokoyama· 3 shared J. Poursine-Laurent· 2 shared L. Yang· 2 shared B. A. Parikh· 1 shared B. Miao· 1 shared B. Plougastel-Douglas· 1 shared C.-H. Yao· 1 shared D. L. Beckman· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

W. M. Yokoyama

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4 papers

Recent·Most cited

The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function

S. Li, M. Bern, B. Miao, T. Inoue, S. J. Piersma, M. Colonna, T. Kurosaki, W. M. Yokoyama

This study shows Bach2 negatively regulates NK cell maturation and function by correlating with TCF1 and opposing effector molecule and cell cycle gene expression.

bioRxiv · Feb 14, 2022 · PreprintImmunology

NK cell metabolic adaptation to infection promotes survival and viral clearance.

F. Victorino, T. Bigley, E. Park, C.-H. Yao, J. Benoit, L.-P. Yang, S. J. Piersma, E. J. Lauron, R. M. Davidson, G. J. Patti, W. M. Yokoyama

This study shows HIF-1 is essential for NK cell survival and viral clearance during MCMV infection by regulating metabolism and preventing apoptosis.

bioRxiv · Mar 17, 2021Immunology

Virus infection is controlled by cell type-specific sensing of murine cytomegalovirus through MyD88 and STING

S. J. Piersma, J. Poursine-Laurent, L. Yang, G. Barber, W. M. Yokoyama

This study shows that MyD88 and STING control murine cytomegalovirus in different cell types, with STING also acting in non-hematological stromal cells.

bioRxiv · Mar 24, 2020Immunology

Major histocompatibility complex class I-restricted protection against murine cytomegalovirus requires missing-self recognition by the natural killer cell inhibitory Ly49 receptors

B. A. Parikh, M. D. Bern, S. J. Piersma, L. Yang, D. L. Beckman, J. Poursine-Laurent, B. Plougastel-Douglas, W. M. M. Yokoyama

This study shows that NK cell inhibitory Ly49 receptors are essential for controlling MCMV infection in an MHC-restricted manner, supporting the missing-self hypothesis.

bioRxiv · Sep 4, 2019 · PreprintImmunology