Author

S. J. Pitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:electrophysiology· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

U. Zachariae· 2 shared A. I. S. Sobczak· 1 shared A. J. Stewart· 1 shared A. Morton· 1 shared B. Casement· 1 shared C. A. Blindauer· 1 shared C. M. Ives· 1 shared C. S. Tucker· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

U. Zachariae

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The SARS-CoV-2 envelope (E) protein forms a calcium- and voltage-activated calcium channel

L. H. Antonides, Q. W. Hurst, C. M. Ives, K. Ramberg, N. Ostrovitas, E. Scanlan, M. Caffrey, S. J. Pitt, U. Zachariae

This study identifies the SARS-CoV-2 E protein as a calcium- and voltage-activated ion channel that releases Ca2+ from the ER, suggesting it as a potential target for antiviral therapies.

bioRxiv · Oct 11, 2022 · PreprintBiophysics

Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

A. I. S. Sobczak, K. G. H. Katundu, F. A. Phoenix, S. Khazaipoul, R. Yu, F. Lampiao, F. Stefanowicz, C. A. Blindauer, S. J. Pitt, T. K. Smith, R. A. Ajjan, A. J. Stewart

The paper shows that elevated NEFA levels in T2DM alter plasma zinc speciation, increasing coagulability and thrombotic risk.

bioRxiv · Jul 27, 2020 · PreprintBiochemistry

A new family of Type VI secretion system-delivered effector proteins displays ion-selective pore-forming activity

G. Mariano, K. Trunk, D. J. Williams, L. Monlezun, H. Strahl, S. J. Pitt, S. J. Coulthurst

The paper identifies Ssp6 as an ion-selective pore-forming toxin delivered by the T6SS of Serratia marcescens, showing it causes membrane depolarization and increased permeability.

bioRxiv · Jun 20, 2019 · PreprintMicrobiology

Monitoring contractility in single cardiomyocytes and whole hearts with bio-integrated microlasers

M. Schubert, L. Woolfson, I. R. Barnard, A. Morton, B. Casement, G. B. Robertson, G. B. Miles, S. J. Pitt, C. S. Tucker, M. C. Gather

This paper introduces microlasers to monitor cardiac contractility in single cells and whole hearts, revealing sarcomeric protein density changes as a key factor in contraction.

bioRxiv · Jun 17, 2019Biophysics

Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE

G. Tamburrino, S. Llabres, O. N. Vickery, S. J. Pitt, U. Zachariae

This study characterizes the electrophysiological properties of MtrE and MtrC in Neisseria gonorrhoeae, showing their role in antibiotic efflux and identifying potential targets for inhibitors.

bioRxiv · Oct 25, 2017Biophysics