Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells
R. J. Kumar, H. X. Chao, V. R. Roberts, A. R. Sullivan, S. J. Shah, D. A. Simpson, W. Feng, A.-S. Wozny, S. Kumar, J. E. Purvis, G. P. Gupta
The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.
bioRxiv · Apr 1, 2020 · PreprintCell Biology