Author

G. P. Gupta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. A. Simpson· 2 shared J. E. Purvis· 2 shared R. J. Kumar· 2 shared W. Feng· 2 shared A. DeMichele· 1 shared A. Hall· 1 shared A. Khan· 1 shared A. M. Goddard· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

D. A. Simpson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

M.-G. Cho, R. J. Kumar, C.-C. Lin, J. A. Boyer, J. A. Shahir, K. Fagan-Solis, D. A. Simpson, C. Fan, C. E. Foster, A. M. Goddard, Q. Wang, Y. Wang, A. Y. Ho, P. Liu, c. J. perou, , G. P. Gupta

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

bioRxiv · Dec 9, 2022Cell Biology

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

S. H. Strand, B. Rivero-Gutierrez, K. E. Houlahan, J. A. Seoane, L. M. King, T. Risom, L. A. Simpson, S. Vennam, A. Khan, L. Cisneros, T. Hardman, B. Harmon, F. Couch, K. Gallagher, M. Kilgore, , K Owzar

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

bioRxiv · Jun 16, 2021 · PreprintCancer Biology

CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies

G. A. Breuer, J. Bezney, N. R. Fons, R. K. Sundaram, W. Feng, G. P. Gupta, R. S. Bindra

This study identifies novel PARP inhibitor classifications based on distinct base excision repair pathway dependencies revealed through CRISPR screening, showing that PARP trapping and catalytic inhibition are not the only factors affecting their biological activity.

bioRxiv · Oct 18, 2020 · PreprintCancer Biology

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

R. J. Kumar, H. X. Chao, V. R. Roberts, A. R. Sullivan, S. J. Shah, D. A. Simpson, W. Feng, A.-S. Wozny, S. Kumar, J. E. Purvis, G. P. Gupta

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

bioRxiv · Apr 1, 2020 · PreprintCell Biology