Author

J. E. Purvis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 6 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:imaging· 3 Approach:microscopy & imaging analysis· 3 Approach:statistical model· 3

Frequent Co-Authors

J. C. Limas· 3 shared J. G. Cook· 3 shared K. M. Kedziora· 3 shared W. Stallaert· 3 shared C. D. Taylor· 2 shared C. L. Young· 2 shared D. A. Simpson· 2 shared G. P. Gupta· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

J. C. Limas

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells

T. M. Zikry, S. C. Wolff, J. S. Ranek, H. Davis, A. Naugle, A. A. Whitman, M. R. Kosorok, P. M. Spanheimer, J. E. Purvis

This study identifies cell cycle plasticity as a mechanism for fractional resistance to palbociclib in ER+/HER2- breast tumor cells using single-cell imaging and computational analysis.

bioRxiv · May 22, 2023Cancer Biology

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

M.-G. Cho, R. J. Kumar, C.-C. Lin, J. A. Boyer, J. A. Shahir, K. Fagan-Solis, D. A. Simpson, C. Fan, C. E. Foster, A. M. Goddard, Q. Wang, Y. Wang, A. Y. Ho, P. Liu, c. J. perou, , G. P. Gupta

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

bioRxiv · Dec 9, 2022Cell Biology

The molecular architecture of cell cycle arrest

W. Stallaert, S. R. Taylor, K. M. Kedziora, M. S. Johnson, C. D. Taylor, H. K. Sobon, C. L. Young, J. C. Limas, J. Varblow Holloway, J. G. Cook, J. E. Purvis

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

bioRxiv · Apr 27, 2022Cell Biology

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics

J. Burclaff, R. J. Bliton, K. A. Breau, M. T. Ok, I. Gomez-Martinez, J. S. Ranek, A. P. Bhatt, J. E. Purvis, J. T. Woosley, S. T. Magness

The paper uses single-cell transcriptomics to analyze healthy adult human small intestine and colon epithelium, identifying lineage markers, regional differences, and functional variations across anatomical regions.

bioRxiv · Oct 5, 2021Physiology

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

T. P. Enrico, W. Stallaert, E. T. Wick, P. Ngoi, S. M. Rubin, N. G. Brown, J. E. Purvis, M. J. Emanuele

This study identifies cyclin F as a regulator of p130/RBL2 degradation via SCF, showing its role in cell cycle control and potential implications in cancer.

bioRxiv · Apr 23, 2021Cell Biology

The structure of the human cell cycle

W. Stallaert, K. M. Kedziora, C. D. Taylor, T. M. Zikry, H. K. Sobon, S. R. Taylor, C. L. Young, J. C. Limas, J. G. Cook, J. E. Purvis

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

bioRxiv · Feb 11, 2021Cell Biology

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

R. J. Kumar, H. X. Chao, V. R. Roberts, A. R. Sullivan, S. J. Shah, D. A. Simpson, W. Feng, A.-S. Wozny, S. Kumar, J. E. Purvis, G. P. Gupta

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

bioRxiv · Apr 1, 2020 · PreprintCell Biology

Autophagy regulates the localization and degradation of p16INK4a

P. R. Coryell, S. K. Goraya, K. A. Griffin, M. A. Redick, S. R. Sisk, J. E. Purvis

This study shows autophagy regulates p16INK4a localization and degradation via lysosomal pathways, affecting cellular senescence and disease.

bioRxiv · Jan 15, 2019Cell Biology

Precise detection of S phase onset reveals decoupled G1/S transition events

G. D. Grant, K. M. Kedziora, J. C. Limas, J. E. Purvis, J. G. Cook

The paper introduces PIP-FUCCI, a new reporter system for precise detection of S phase onset, revealing that APCCdh1 inactivation is not strictly required for S phase entry.

bioRxiv · Apr 12, 2018Cell Biology