Author

S. J. Smerdon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. A. E. Westrip· 2 shared M. L. Coleman· 2 shared A. Kaur· 1 shared A. M. Couturier· 1 shared A. Zayer· 1 shared C. D. Eaton· 1 shared D. G. Wilkinson· 1 shared E. Hendrix· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

C. A. E. Westrip

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rewiring protein binding specificity in paralogous DRG/DFRP complexes

C. A. E. Westrip, S. J. Smerdon, M. L. Coleman

The paper identifies structural determinants enabling DRG1 to switch binding specificity from DFRP1 to DFRP2 through targeted mutations.

bioRxiv · May 31, 2023Biochemistry

A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis

E. Hendrix, R. Andrijes, U. Boora, A. Kaur, J. R. Bundred, L. Officer-Jones, r. pennie, I. Powley, A. Zayer, R. Heilig, C. A. E. Westrip, S. F. Fletcher, C. D. Eaton, T. J. Kennedy, S. Piasecka, , M. L. Coleman

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

bioRxiv · Mar 15, 2023 · PreprintCell Biology

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

M. Fournier, J.-Y. Bleuyard, A. M. Couturier, J. Ellins, S. Hester, S. J. Smerdon, L. Tora, F. Esashi

This study shows that KAT2A/B acetylates PALB2 to regulate its chromatin association, enhancing DNA repair and genome stability.

bioRxiv · Jan 21, 2020Cell Biology

Btbd6-dependent Plzf recruitment to Cul3 E3 ligase complexes through BTB domain heterodimerization

M. S. Ismail, S. R. Martin, N. J. Ball, I. A. Taylor, S. Howell, D. G. Wilkinson, S. J. Smerdon

This paper identifies a mechanism where Btbd6 recruits Plzf to Cul3 E3 ligase complexes through BTB domain heterodimerization, enabling Plzf ubiquitination.

bioRxiv · Mar 12, 2019 · PreprintBiochemistry